The global spread of antimicrobial resistance (AMR) among pathogenic bacteria is recognized as one of the biggest concerns in public health and a research priority in microbiology. Drug-resistance increases exponentially for certain bacterial organisms and is becoming the main threat to human health worldwide. As a consequence, national and international authorities have emphasized the need to taking a broad, coordinated approach to develop new antimicrobial strategies to fight against drug-resistant bacteria across multiple sectors such as human health and animal health, agriculture and environment1 (i.e. ‘One health’ major challenge). The STARS-TAP research program aims at developing an innovative non-antibiotic antibacterial methodology to specifically target AMR strains from natural bacterial communities in several ecosystems in situ. The proposed methodology is based on Targeted-Antibacterial-Plasmids (TAPs) that use DNA conjugation to deliver CRISPR/Cas systems exerting a strain-specific antibacterial activity. If successful, our research would represent a real breakthrough for clinical and environmental microbiology, and open new options for the elimination of AMR strains from various ecosystems. This unexplored and versatile strategy complementary to antibiotic treatments holds the potential to be used for curative or preventive decolonization purposes, or even in agriculture to tackle AMR prevalence in amended soils.

PARTENAIRES

• Unité Microbiologie Moléculaire et Biochimie Structurale, Lyon (France) - Coordinateur
• Laboratoire d'Ecologie Microbienne, Lyon (France)
• CHU UCL Namur (Belgium)
• Institute of Soil Science and Plant Cultivation, Pulawy (Poland)
• Unit of Pharmacology of Antimicrobial Agents and Antibioresistance, Poitiers (France)

FINANCEMENT

The Joint Programming Initiative on Antimicrobial Resistance (JPIAMR)
Call 2021 - One Health interventions to prevent or reduce the development and transmission of AMR